Consideration could be given to developing continuing education materials for healthcare providers, staff at clozapine clinics, as well as patient and care-giver handouts on the issues of clozapine toxicity during COVID-19 and the contraindication of concomitantly prescribing Paxlovid ® with clozapine
Schizophrenia
Clozapine has a major metabolite, N-desmethylclozapine (NMDC, norclozapine), which has activity comparable to clozapine at the D2 and 5-HT2A receptors as well as at several other receptors []; both the metabolite and parent drug can activate N-methyl-D-aspartate (NMDA) glutamate receptors []
Clozapine Clozaril, Versacloz Contact psychiatry PharmD Iloperidone Fanapt Contact psychiatry PharmD for case-by-case management based on indication Start Paxlovid at 24 – 48 hours from time of last dose of CNI or mTOR inhibitor (see table below) 4) Check CNI or mTOR inhibitor level per table below and restart when appropriate Paxlovid is a combination antiviral medication that contains nirmatrelvir (a protease inhibitor ) and ritonavir (originally used to treat HIV infections)
Bowel obstruction: clozapine can cause slowing of bowel movement resulting in constipation, blockage and a ‘paralytic ileus’ which may be fatal
This side effect can result in a decrease in the number of white blood cells (infection-fighting cells) in your body
You should avoid activities requiring mental alertness until you know how these Introduction and background
3 At the same time community pharmacies became
2 and 4
The median duration of exposure was 42 days for clozapine tablets and chlorpromazine
To the Editors, A 45-year-old African American female (BMI = 28
4% of patients with schizophrenia in the U